Prostaglandin E1: Uses and Benefits in Medicine

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What is prostaglandin E1 (PGE1)?

Prostaglandin E1 ( PGE1) is a naturally occurring prostaglandin and is also used as a medication ( alprostadil ). In infants with congenital heart defects, it is delivered by slow injection into a vein to open the ductus arteriosus until surgery can be carried out.

Is prostaglandin E 1 a vasodilator?

Prostaglandin E 1 is in the vasodilator family of medications. It works by opening blood vessels and relaxing smooth muscle. Prostaglandin E 1 was isolated in 1957 and approved for medical use in the United States in 1981. It is on the World Health Organization's List of Essential Medicines.

How is prostaglandin E 1 biosynthesized?

Prostaglandin E 1 is biosynthesized on an as-needed basis from dihomo-γ-linolenic acid (an omega-6 fatty acid) in healthy humans without coronary artery disease and/or a genetic disorder .

Can prostaglandin E1 be used for erectile dysfunction?

The use of prostaglandin E1 (PGE1) for erectile dysfunction and its side effects requires thorough discussion with patients. There are relatively common pre-existing conditions such as cardiovascular disease that are contraindicated or cautioned with PGE1.

What is prostaglandin E1 used for?

Prostaglandin E1 (PGE1) is used to keep the ductus arteriosus patent and can be life‐saving in neonates with ductal‐dependent cardiac lesions. PGE1 is used to promote mixing of pulmonary and systemic blood flow or improve pulmonary or systemic circulations, prior to balloon atrial septostomy or surgery.

What is prostaglandin E 1 (PGE)?

Prostaglandin E 1 (PGE 1) is a potent vasodilator and activates, in contrast to prostacyclin (which binds selectively to the prostacyclin (IP) receptor), the prostaglandin E 1 (EP) receptor.

Does prostaglandin E1 maintain ductal patency in critical congenital heart disease?

Prostaglandin E1 is used to maintain ductal patency in critical congenital heart disease (CHD). The standard starting dose of prostaglandin E1 is 0.05 µg/kg/minute. Lower doses are frequently used, but the efficacy and safety of a low-dose regimen of prostaglandin E1 has not been established.

What Is Prostaglandin E1

1. https://my.clevelandclinic.org/health/articles/24411-prostaglandins
2. https://en.wikipedia.org/wiki/Prostaglandin_E1
3. https://www.ncbi.nlm.nih.gov/books/NBK546629/
4. https://www.sciencedirect.com/topics/medicine-and-dentistry/prostaglandin-e1
5. https://www.statpearls.com/point-of-care/27826
6. https://www.cochrane.org/CD011417/NEONATAL_prostaglandin-e1-keeping-duct-open-heart-conditions-newborn
7. https://www.yourhormones.info/hormones/prostaglandins/

Prostaglandin E1 Information

1. https://www.cambridge.org/core/journals/cardiology-in-the-young/article/abs/lowdose-prostaglandin-e1-is-safe-and-effective-for-critical-congenital-heart-disease-is-it-time-to-revisit-the-dosing-guidelines/D5088CD79C754F6313F983B758729981
2. https://europepmc.org/article/nbk/nbk546629