DNA Fragmentation Test - Evaluating Sperm DNA Integrity

DNA fragmentation test is a diagnostic assessment that evaluates the integrity of sperm DNA. It helps in assessing male fertility potential and identifying issues that may impact fertility.
Category
Medical Test
Where to get
Available in specialized fertility clinics
Prepared by Nick Harper, reviewed by Dr. David James Simpson

DNA fragmentation test FAQ


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What is a DNA fragmentation test?

A DNA fragmentation test may be a single test or as part of a series of tests being performed on you and your partner to assess your chances of achieving a pregnancy as a couple. This test is recommended for all men over the age of 45 but is also suitable for couples who have been trying to conceive for one year or are considering IVF treatment.

What is a sperm DNA fragmentation test?

Sperm DNA fragmentation is an advanced test used to determine the damage or “fragmentation” of sperm. While sperm might show good results when looking at motility and volume during a semen analysis, a DNA fragmentation test for sperm may reveal other damage which may negatively impact the sperm’s ability to fertilise an egg.

What is the difference between DNA fragmentation and spermqt?

DNA Fragmentation identifies chromosomal breaks and is recommended later in the fertility journey in cases of recurrent pregnancy loss. SpermQT (Sperm Quality Test) is a test that examines abnormalities in sperm gene function and is recommended in the initial stage of the fertility journey.

When is a DNA fragmentation test recommended?

This test is recommended for all men over the age of 45 but is also suitable for couples who have been trying to conceive for one year or are considering IVF treatment. A DNA fragmentation test is also highly recommended for patients who are experiencing recurrent spontaneous miscarriages or unexplained (idiopathic) infertility.

Is a sperm DNA fragmentation test safe?

With in-depth knowledge about your sperm health, your doctor can help you navigate the best next steps in your fertility journey. Furthermore, there are no known risks associated with a sperm DNA fragmentation test for male patients. The HFEA does provide additional information. How much does a sperm DNA fragmentation test cost?

DNA fragmentation test References

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